Objective: To evaluate secondary exposure of testosterone transferred to females from a male partner, dosed with 1.62% testosterone gel after direct skin-to-skin contact with the application site, and to investigate the effect of wearing a t-shirt on testosterone transfer.
Research design and methods: Across three studies, a total of 72 healthy males applied 5.0 g 1.62% testosterone gel to their abdomen alone, upper arms/shoulders alone, or a combination of their upper arms/shoulders and abdomen (single dose or once daily for 7 days). Male-female contact occurred 2 or 12 hours after testosterone gel application, with males either wearing or not wearing a t-shirt. There were 15 minutes of supervised contact with the application site between the male and his female partner. Blood samples were collected over a 24 hour period in females for assessment of serum testosterone levels at baseline and after contact.
Conclusions: There is a risk of testosterone transfer from males using 1.62% testosterone gel to others who come in contact with the application site for at least 12 hours after application. Secondary exposure can be mitigated by means of a t-shirt barrier.
Pocatello, Idaho - The University of Utah Indoor Track & Field team finished competition at the Mountain State Games on Sat. Feb. 2. The meet began on Friday. The top finisher for Friday was Kristy Slade placing first (5.56m) in the pentathlon long jump, second (1.62m) in the pentathlon high jump, and second overall in the pentathlon. Erianne Allen finished second (2:22.47) in the pentathlon 800-meter run and Brooke LoBue placed third (12-00.00) in the pole vault. Top finishers for Saturday included Nephi Tyler placing first (4:10.00) in the one mile run, April Jackson placing second (5-07.00) in the high jump and Audrey Kiser placing second (58-02.00) in the weight throw.
PreviouslyIn the last episode, we wrote a TypeScript implementation for the Monkey Language.Let's review some numbers, shall we?Since I started this series, most languages and runtimes have released new versions. On the other hand, I did some...
All-cause mortality was higher in people with schizophrenia versus any non-schizophrenia control group (RR=2.52, 95% CI: 2.38-2.68, n=79) in 135 studies spanning 1957 to 2021 (schizophrenia: N=4,536,447; general population controls: N=1,115,600,059; other psychiatric illness controls: N=3,827,955), with the highest risk in first-episode (RR=7.43, 95% CI: 4.02-13.75, n=2) and incident (i.e., earlier-phase) schizophrenia (RR=3.52, 95% CI: 3.09-4.00, n=7) versus the general population. Suicide or injury-poisoning or an undetermined non-natural cause had the highest risk of death (RR=9.76-8.42), followed by pneumonia among natural causes (RR=7.00, 95% CI: 6.79-7.23), infectious or endocrine or respiratory or urogenital or diabetes causes (RR=3 to 4), alcohol or gastrointestinal or renal or nervous system or cardio-cerebrovascular or all-natural causes (RR=2 to 3), and liver or cerebrovascular, With each study year, all-cause mortality increased modestly but considerably (beta=0.0009, 95% CI:0.001-0.02, P=0.02). In incident schizophrenia samples, those under the age of 40 had greater all-cause and suicide-related mortality than those under the age of 40, and a higher percentage of females had a higher suicide-related mortality risk. In incident schizophrenia, all-cause mortality was greater than in prevalent schizophrenia (RR=3.52 vs. 2.86, P=0.009). All-cause mortality increased with comorbid drug use disorder (RR=1.62, 95% CI: 1.47-1.80, n=3). Antipsychotics were found to be protective against all-cause mortality (RR=0.71, 95% CI: 0.59-0.84, n=11), with the largest effects for second-generation long-acting injectable antipsychotics (SGA-LAIs) (RR=0.39, 95% CI: 0.27-0.56, n=3), clozapine (RR=0.43, 95% CI: 0.34-0.55, n=3), any LAI (RR Although antipsychotics were found to be protective against natural cause mortality, first-generation antipsychotics (FGAs) were linked to increased suicide and natural cause death in incident schizophrenia.